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Tirzepatide activates both GLP-1 and GIP receptors (dual agonist), while semaglutide activates only GLP-1

138 SIRT5-mediated IDH2 desuccinylation also regulates cellular NADPH homeostasis and redox potential

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This activation may result in excessive protein degradation or muscle atrophy, particularly in vulnerable populations such as the elderly or individuals with chronic illnesses [35]